Long COVID is a persistent multisystem illness following SARS-CoV-2 infection, with fatigue, cognitive "brain fog", sleep disturbance and pain. A randomised controlled trial reported improvements in cognition, sleep, pain and overall symptom burden after 40 HBOT sessions, sustained at one year. Evidence is currently anchored to a single research group; independent replication is awaited. Investigational.

Evidence Level B Emerging Evidence

Evidence summary

Persistent multisystem symptoms following acute SARS-CoV-2 infection — including fatigue, cognitive dysfunction ("brain fog"), sleep disturbance, and pain. A 2022 randomised controlled trial reported significant improvements in cognitive function, sleep, pain, and overall symptom burden after 40 HBOT sessions, with benefits sustained at one-year follow-up. The evidence base is currently anchored to a single research group; independent replication is awaited (HOT-LoCO trial in progress).

Treatment protocol

Protocol

Pressure

2.0 ATA

Duration

90 min

Sessions

Frequency

5×/week

Evidence basis: Zilberman-Itskovich et al., 2022 (RCT)

References:

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See full citations on the references page.

Last updated: 30 May 2026