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Bibliography

Complete References

All 64 peer-reviewed sources cited in this clinical resource, with direct links to original publications.

64

Total Sources

23

RCTs & Meta-Analyses

27

Reviews & Meta-Analyses

1

Clinical Guidelines

  1. 1
    Reference Book

    Hyperbaric Physiological And Pharmacological Effects of Gases.

    Kahle AC, Cooper JS. · StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing · 2023

    View Source
    Cited in: Neovascularization & Angiogenesis · Antimicrobial Activity · Gas Volume Reduction · Hyperoxygenation & Vasoconstriction · Air or Gas Embolism · Carbon Monoxide Poisoning · Central Retinal Artery Occlusion · Clostridial Myositis & Myonecrosis (Gas Gangrene) · Compromised Skin Grafts & Flaps · Crush Injury & Compartment Syndrome · Decompression Sickness · Delayed Radiation Injury (Soft Tissue & Bony Necrosis) · Enhancement of Healing in Selected Problem Wounds · Exceptional Blood Loss Anemia · Idiopathic Sudden Sensorineural Hearing Loss · Intracranial Abscess · Necrotizing Soft Tissue Infections · Refractory Osteomyelitis · Dermatology · Plastic Surgery · Surgery Sector · Women's Health
  2. 2
    Review Article

    A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities.

    Ortega MA, Fraile-Martinez O, García-Montero C, et al. · Medicina · 2021

    View Source
    Cited in: Neovascularization & Angiogenesis · Air or Gas Embolism · Carbon Monoxide Poisoning · Clostridial Myositis & Myonecrosis (Gas Gangrene) · Decompression Sickness · Delayed Radiation Injury (Soft Tissue & Bony Necrosis) · Necrotizing Soft Tissue Infections · Dermatology · ENT (Otolaryngology) · Ophthalmology · Plastic Surgery · Surgery Sector · Women's Health
  3. 3
    Prospective Clinical Study

    Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.

    Hachmo Y, Hadanny A, Abu Hamed R, et al. · Aging (Albany NY) · 2020

    View Source
    Cited in: Anti-Aging & Cellular Regeneration · Senescent Cell Clearance · Telomere Lengthening · Geriatric Assessment
  4. 4
    Randomized Controlled Trial

    Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.

    Hadanny A, Daniel-Kotovsky M, Suzin G, et al. · Aging (Albany NY) · 2020

    View Source
    Cited in: Cognitive Enhancement · Geriatric Assessment · Neurology
  5. 5
    Comprehensive Review

    Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics.

    Fu Q, Duan R, Sun Y, Li Q. · Redox Biology · 2022

    View Source
    Cited in: Anti-Aging & Cellular Regeneration · Geriatric Assessment
  6. 6
    Clinical Study

    Hyperbaric air mobilizes stem cells in humans; a new perspective on the hormetic dose curve.

    MacLaughlin KJ, Barton GP, Braun RK, et al. · Frontiers in Neurology · 2023

    View Source
    Cited in: Anti-Aging & Cellular Regeneration · Stem Cell Mobilization
  7. 7
    Systematic Review & Meta-analysis

    Hyperbaric oxygen therapy for chronic wounds.

    Kranke P, Bennett MH, Martyn-St James M, et al. · Cochrane Database of Systematic Reviews · 2015

    View Source
    Cited in: Enhancement of Healing in Selected Problem Wounds · Dermatology · Endocrinology & Metabolism
  8. 8
    Review Article

    Hyperbaric oxygen treatment — from mechanisms to cognitive improvement.

    Gottfried I, Schottlender N, Ashery U. · Biomolecules · 2021

    View Source
    Cited in: Cognitive Enhancement · Neurology · Psychiatry & Psychology
  9. 9
    Clinical Guidelines

    Hyperbaric Medicine Indications Manual (15th Edition).

    Undersea and Hyperbaric Medical Society (UHMS); Huang E, ed. · Best Publishing Company · 2024

    View Source
    Cited in: Acute Thermal Burns · Air or Gas Embolism · Avascular Necrosis of the Femoral Head · Carbon Monoxide Poisoning · Central Retinal Artery Occlusion · Clostridial Myositis & Myonecrosis (Gas Gangrene) · Compromised Skin Grafts & Flaps · Crush Injury & Compartment Syndrome · Decompression Sickness · Delayed Radiation Injury (Soft Tissue & Bony Necrosis) · Enhancement of Healing in Selected Problem Wounds · Exceptional Blood Loss Anemia · Idiopathic Sudden Sensorineural Hearing Loss · Intracranial Abscess · Necrotizing Soft Tissue Infections · Refractory Osteomyelitis · Dermatology · Endocrinology & Metabolism · ENT (Otolaryngology) · Medical Oncology · Ophthalmology · Plastic Surgery · Surgery Sector · Women's Health
  10. 10
    Randomized Controlled Trial

    Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial.

    Multiple Authors. · Scientific Reports · 2025

    View Source
    Cited in: Surgery Sector
  11. 11
    Preclinical Study

    Hyperbaric oxygen enhances collagen III formation in wound of ZDF rat.

    Růžička J, Grajciarová M, Vištejnová L, et al. · Physiological Research · 2021

    View Source
    Cited in: Collagen Production & Skin Health
  12. 12
    Review Article

    Application and progress of hyperbaric oxygen therapy in cardiovascular diseases.

    Tian M, Du W, Yang S, et al. · Medical Gas Research · 2025

    View Source
    Cited in: Surgery Sector
  13. 13
    Systematic Review

    Hyperbaric oxygen for the treatment of diabetic foot ulcers: a systematic review.

    Stoekenbroek RM, Santema TB, Legemate DA, et al. · European Journal of Vascular and Endovascular Surgery · 2014

    View Source
    Cited in: Enhancement of Healing in Selected Problem Wounds · Dermatology · Endocrinology & Metabolism
  14. 14
    Systematic Review & Meta-Analysis

    Hyperbaric oxygen therapy in inflammatory bowel disease: a systematic review and meta-analysis.

    Singh AK, Jha DK, Jena A, et al. · European Journal of Gastroenterology & Hepatology · 2021

    View Source
    Cited in: Gastroenterology
  15. 15
    Clinical Trial Review

    Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials.

    Figueroa XA, Wright JK. · Neurology · 2016

    View Source
    Cited in: Traumatic Brain Injury & Post-Concussion Syndrome · Neurology
  16. 16
    Clinical Study

    Protective effect of hyperbaric oxygen therapy on cognitive function in patients with vascular dementia.

    Xu Y, Wang Q, Qu Z, et al. · Cell Transplantation · 2019

    View Source
    Cited in: Neurology
  17. 17
    Retrospective Study

    Hyperbaric oxygen therapy for managing cancer treatment complications: a safety evaluation.

    Canarslan Demir K, Avci AU, Ozgok Kangal MK, et al. · Medicina (Kaunas) · 2025

    View Source
    Cited in: Medical Oncology
  18. 18
    Preclinical Study

    Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice.

    Multiple Authors. · Cell Stress and Chaperones · 2015

    View Source
    Cited in: Endocrinology & Metabolism
  19. 19
    Clinical Review

    Hyperbaric oxygen therapy for central retinal artery occlusion: patient selection and perspectives.

    Celebi ARC. · Clinical Ophthalmology · 2021

    View Source
    Cited in: Central Retinal Artery Occlusion · Ophthalmology
  20. 20
    Systematic Review

    Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus.

    Bennett MH, Kertesz T, Perleth M, et al. · Cochrane Database of Systematic Reviews · 2012

    View Source
    Cited in: Idiopathic Sudden Sensorineural Hearing Loss · ENT (Otolaryngology)
  21. 21
    Randomized Controlled Trial

    Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial.

    Hadanny A, Sasson E, Copel L, Daniel-Kotovsky M, et al. · BMC Geriatrics · 2024

    View Source
    Cited in: Geriatric Assessment
  22. 22
    Systematic Review & Meta-Analysis

    Effects of pre-, post- and intra-exercise hyperbaric oxygen therapy on performance and recovery: a systematic review and meta-analysis.

    Huang X, Wang R, Zhang Z, Wang G, Gao B. · Frontiers in Physiology · 2021

    View Source
    Cited in: Athletic Performance & Recovery
  23. 23
    Review Article

    Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging.

    Gupta M, Rathored J. · Frontiers in Aging · 2024

    View Source
    Cited in: Anti-Aging & Cellular Regeneration
  24. 24
    Systematic Review

    Hyperbaric oxygen therapy for acute ischaemic stroke.

    Bennett MH, Weibel S, Wasiak J, et al. · Cochrane Database of Systematic Reviews · 2014

    View Source
    Cited in: Chronic Post-Stroke Recovery · Neurology
  25. 25
    RCT

    Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

    Zilberman-Itskovich S, Catalogna M, Sasson E, et al. · Scientific Reports · 2022

    View Source
    Cited in: Long COVID · Neurology
  26. 26
    RCT Follow-up

    Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial.

    Hadanny A, Zilberman-Itskovich S, Catalogna M, et al. · Scientific Reports · 2024

    View Source
    Cited in: Long COVID · Neurology
  27. 27
    Clinical Review

    Hyperbaric oxygen effectively addresses the pathophysiology of long COVID: clinical review.

    Katz AA, Wainwright S, Kelly MP, et al. · Frontiers in Medicine · 2024

    View Source
    Cited in: Long COVID · Neurology
  28. 28
    Trial Protocol

    Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trial.

    Kjellberg A, Abdel-Halim L, Hassler A, et al. · BMJ Open · 2022

    View Source
    Cited in: Long COVID · Neurology
  29. 29
    Prospective Clinical Trial

    Hyperbaric oxygen therapy can diminish fibromyalgia syndrome — prospective clinical trial.

    Efrati S, Golan H, Bechor Y, et al. · PLOS ONE · 2015

    View Source
    Cited in: Fibromyalgia · Neurology
  30. 30
    Meta-analysis

    Effectiveness of hyperbaric oxygen for fibromyalgia: a meta-analysis of randomized controlled trials.

    Cao C, Li Q, Zhang X, et al. · Clinics and Practice · 2023

    View Source
    Cited in: Fibromyalgia · Neurology
  31. 31
    Systematic Review & Meta-analysis

    Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-analysis.

    Chen X, You J, Ma H, et al. · BMJ Open · 2023

    View Source
    Cited in: Fibromyalgia · Neurology
  32. 32
    Randomized Controlled Trial

    Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: a randomized, controlled trial.

    Ablin J, Lang E, Catalogna M, et al. · PLOS ONE · 2023

    View Source
    Cited in: Fibromyalgia · Neurology
  33. 33
    Review Article

    The use of hyperbaric oxygen therapy in the treatment of necrotizing soft tissue infections, compromised grafts and flaps, hidradenitis suppurativa, and pyoderma gangrenosum.

    Goggins C, Khachemoune A. · Acta Dermatovenerologica Alpina Pannonica et Adriatica · 2019

    View Source
    Cited in: Compromised Skin Grafts & Flaps · Inflammatory Dermatoses · Necrotizing Soft Tissue Infections · Dermatology · Plastic Surgery
  34. 34
    Review Article

    The supporting role of hyperbaric oxygen therapy in atopic dermatitis treatment.

    Zwoliński M, Hovagimyan A, Ignatowicz J, et al. · Journal of Clinical Medicine · 2025

    View Source
    Cited in: Inflammatory Dermatoses · Dermatology
  35. 35
    Clinical Study

    Effects of hyperbaric oxygen therapy in children with severe atopic dermatitis.

    Mews J, Tomaszewska A, Siewiera J, et al. · Journal of Clinical Medicine · 2021

    View Source
    Cited in: Inflammatory Dermatoses · Dermatology
  36. 36
    Case Report

    Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature.

    Butler G, Chávarri Michaels J, Al-Waili N, et al. · Journal of Medical Case Reports · 2009

    View Source
    Cited in: Inflammatory Dermatoses · Dermatology
  37. 37
    Case-Control Study

    Assessing the efficacy of hyperbaric oxygen therapy on facelift outcomes: a case–control study comparing outcomes in patients with and without hyperbaric oxygen therapy.

    Neel OF, Mousa AH, Al-Terkawi RA, et al. · Aesthetic Surgery Journal Open Forum · 2023

    View Source
    Cited in: Aesthetic & Reconstructive Recovery · Plastic Surgery
  38. 38
    Review Article

    Hyperbaric oxygen therapy for the compromised graft or flap.

    Francis A, Baynosa RC. · Advances in Wound Care · 2017

    View Source
    Cited in: Aesthetic & Reconstructive Recovery · Compromised Skin Grafts & Flaps · Dermatology · Plastic Surgery
  39. 39
    Case Series

    Role of hyperbaric oxygen therapy in cosmetic and reconstructive surgery in ischemic soft tissue wounds: a case series.

    Simman R, Bach K. · Eplasty · 2022

    View Source
    Cited in: Aesthetic & Reconstructive Recovery · Plastic Surgery
  40. 40
    Case Series & Literature Review

    Hyperbaric oxygen therapy in plastic surgery practice: case series and literature overview.

    Bassetto F, Bosco G, Brambullo T, et al. · G Chir · 2019

    View Source
    Cited in: Aesthetic & Reconstructive Recovery · Plastic Surgery
  41. 41
    Preclinical Study

    Remission of endometriosis by hyperbaric oxygen treatment in rats.

    Aydin Y, Atis A, Uludag S, et al. · Reproductive Sciences · 2011

    View Source
    Cited in: Endometriosis · Women's Health
  42. 42
    Preclinical Study

    The effect of hyperbaric oxygen therapy in the inflammatory response in a mouse model of endometriosis: an experimental study.

    Syahrizal D, Mustika C, Ayu Puspita N, et al. · International Journal of Reproductive BioMedicine · 2022

    View Source
    Cited in: Endometriosis · Women's Health
  43. 43
    Trial Registration

    The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain (recruiting since April 2025).

    Sunnybrook Health Sciences Centre. · ClinicalTrials.gov registry · 2025

    View Source
    Cited in: Endometriosis · Women's Health
  44. 44
    Review Article

    Hyperbaric oxygen therapy: side effects defined and quantified.

    Heyboer M, Sharma D, Santiago W, et al. · Advances in Wound Care · 2017

    View Source
  45. 45
    Randomized Controlled Trial

    Hyperbaric oxygen therapy improves symptoms, brain's microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial.

    Doenyas-Barak K, Catalogna M, Kutz I, et al. · PLoS One · 2022

    View Source
    Cited in: Post-Traumatic Stress Disorder (PTSD) · Psychiatry & Psychology
  46. 46
    Randomized Controlled Trial

    Hyperbaric Oxygen Therapy for Veterans With Combat-Associated Posttraumatic Stress Disorder: A Randomized, Sham-Controlled Clinical Trial.

    Doenyas-Barak K, Kutz I, Lang E, et al. · Journal of Clinical Psychiatry · 2024

    View Source
    Cited in: Post-Traumatic Stress Disorder (PTSD)
  47. 47
    Systematic Review & Meta-Analysis

    Effectiveness and safety of hyperbaric oxygen therapy for psychiatric disorders: A systematic review and meta-analysis.

    Al-Shamali HF, Shocker K, Thakkar J, et al. · Psychiatry and Clinical Neurosciences · 2026

    View Source
    Cited in: Post-Traumatic Stress Disorder (PTSD)
  48. 48
    Prospective Observational Study

    A prospective, observational program evaluation of hyperbaric oxygen therapy for veterans with posttraumatic stress disorder.

    Levitt G, Garling H, Stoddard B, Kip KE, Willing AE. · Psychological Trauma: Theory, Research, Practice, and Policy · 2026

    View Source
    Cited in: Post-Traumatic Stress Disorder (PTSD)
  49. 49
    Randomized Controlled Trial

    Hyperbaric oxygen induces late neuroplasticity in post stroke patients — randomized, prospective trial.

    Efrati S, Fishlev G, Bechor Y, et al. · PLoS One · 2013

    View Source
    Cited in: Chronic Post-Stroke Recovery · Neurology · Rehabilitation Medicine
  50. 50
    Feasibility RCT

    Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke.

    Schiavo S, Richardson D, Santa Mina D, et al. · Applied Physiology, Nutrition, and Metabolism · 2020

    View Source
    Cited in: Chronic Post-Stroke Recovery · Neurology · Rehabilitation Medicine
  51. 51
    Randomized Controlled Trial

    Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial.

    Boussi-Gross R, Golan H, Fishlev G, et al. · PLoS One · 2013

    View Source
    Cited in: Traumatic Brain Injury & Post-Concussion Syndrome · Rehabilitation Medicine
  52. 52
    Randomized Controlled Trial

    Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial.

    Hadanny A, Catalogna M, Yaniv S, et al. · Scientific Reports · 2022

    View Source
    Cited in: Traumatic Brain Injury & Post-Concussion Syndrome · Rehabilitation Medicine
  53. 53
    Randomized Controlled Trial

    Randomized, Sham-Controlled, Feasibility Trial of Hyperbaric Oxygen for Service Members With Postconcussion Syndrome: Cognitive and Psychomotor Outcomes 1 Week Postintervention.

    Walker WC, Franke LM, Cifu DX, Hart BB. · Neurorehabilitation and Neural Repair · 2014

    View Source
    Cited in: Traumatic Brain Injury & Post-Concussion Syndrome · Rehabilitation Medicine
  54. 54
    Editorial

    Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder.

    Bennett MH. · Diving and Hyperbaric Medicine · 2018

    View Source
    Cited in: Traumatic Brain Injury & Post-Concussion Syndrome · Rehabilitation Medicine
  55. 55
    Regulatory Statement

    Hyperbaric oxygen therapy: get the facts. Consumer Update, July 2021 (archived copy; the page has since been removed from fda.gov).

    U.S. Food and Drug Administration. · FDA Consumer Updates · 2021

    View Source
    Cited in: Acute Thermal Burns · Avascular Necrosis of the Femoral Head
  56. 56
    Coverage Policy

    National Coverage Determination (NCD) 20.29: Hyperbaric Oxygen Therapy (version 4, effective 3 April 2017).

    Centers for Medicare & Medicaid Services. · Medicare Coverage Database · 2017

    View Source
    Cited in: Acute Thermal Burns · Avascular Necrosis of the Femoral Head
  57. 57
    Systematic Review

    Hyperbaric oxygen therapy for thermal burns.

    Villanueva E, Bennett MH, Wasiak J, Lehm JP. · Cochrane Database of Systematic Reviews · 2004

    View Source
    Cited in: Acute Thermal Burns · Surgery Sector
  58. 58
    Systematic Review

    Hyperbaric oxygen therapy in burn care: a systematic review of current evidence.

    Molina-Vega J, Pferdehirt RE, Vardanian AJ. · Journal of Burn Care & Research · 2026

    View Source
    Cited in: Acute Thermal Burns
  59. 59
    Randomized Controlled Trial

    Hyperbaric oxygen therapy in femoral head necrosis.

    Camporesi EM, Vezzani G, Bosco G, et al. · Journal of Arthroplasty · 2010

    View Source
    Cited in: Avascular Necrosis of the Femoral Head
  60. 60
    Systematic Review & Meta-analysis

    Evidence-supported HBO therapy in femoral head necrosis: a systematic review and meta-analysis.

    Paderno E, Zanon V, Vezzani G, et al. · International Journal of Environmental Research and Public Health · 2021

    View Source
    Cited in: Avascular Necrosis of the Femoral Head
  61. 61
    Systematic Review & Meta-analysis

    Application of hyperbaric oxygen therapy in femoral head necrosis: a systematic review and meta-analysis.

    Cao Y, Tang P, Tan H, et al. · EFORT Open Reviews · 2025

    View Source
    Cited in: Avascular Necrosis of the Femoral Head
  62. 62
    Clinical Study

    Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress.

    Bosco G, Vezzani G, Mrakic Sposta S, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2018

    View Source
    Cited in: Avascular Necrosis of the Femoral Head
  63. 63
    Systematic Review & Meta-analysis

    Hyperbaric oxygenation for tumour sensitisation to radiotherapy.

    Bennett MH, Feldmeier J, Smee RI, Milross C. · Cochrane Database of Systematic Reviews · 2018

    View Source
    Cited in: Medical Oncology
  64. 64
    Prospective Clinical Study

    The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.

    Hachmo Y, Hadanny A, Mendelovic S, et al. · Aging (Albany NY) · 2021

    View Source
    Cited in: Collagen Production & Skin Health
HBOT Science — Bibliography

All references accessed April 2025. DOI links direct to original publications. This resource is intended for clinical and educational purposes only and does not constitute medical advice.