Neovascularization & Angiogenesis

Hyperoxia stimulates VEGF, PDGF, and FGF release, promoting capillary budding and granulation tissue formation in chronic wounds.

Detailed mechanism

Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF) are upregulated under hyperoxic conditions. This cascade promotes new blood vessel formation, critical for wound healing and tissue regeneration.